Septicaemia is probably misnamed as blood poisoning; it is a systemic disease associated with the presence and persistence of pathogenic organisms or their toxins in the blood.
Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection:
The international definitions require that hypotension requiring the
use of vasoactive infusions and a high arterial lactate content be used
to describe septic shock: in General Practice and Urgent Care hypotension
in the presence of presumed infection is an appropriate surrogate to
describe presumed septic shock (3)
NICE state "..Sepsis is a clinical syndrome caused by the body's immune and coagulation systems being switched on by an infection. Sepsis with shock is a life-threatening condition that is characterised by low blood pressure despite adequate fluid replacement, and organ dysfunction or failure. Sepsis is an important cause of death in people of all ages.....
Previous terminology included terms SIRS (systematic inflammatory response syndrome), severe sepsis and septic shock but new terminology suggests using terms sepsis and septic shock only . Sepsis is defined as a life-threatening organ dysfunction due to a dysregulated host response to infection and septic shock as persisting hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) of 65 mmHg or more and having a serum lactate level of greater than 2 mmol/l despite adequate volume resuscitation..."
Septic shock is defined as a subset of sepsis where particularly profound circulatory, cellular and metabolic abnormalities substantially increase mortality.
Last edited 09/2019