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- flecainide use increases digoxin concentration by about 20%
- amiodarone causes a significant increase in plasma concentrations of flecainide
- propranolol co-administration leads to a significant increase in plasma
concentrations of both drugs
- the use of negatively inotropic drugs with flecainide (e.g. verapamil,
propranolol, disopyramide) increases the risk of heart failure (1)
- cimetidine and fluoxetine may also increase flecainide concentrations
- drugs which can prolong the QT interval (e.g. terfenadine, astemizole,
quinine) when used with flecainide further increase the risk of serious ventricular
- Prescribers' Journal (1999), 39 (4), 222-26.
Last reviewed 01/2018