The lipoxygenase enzymes are based in the cytosol of the lung, platelets and leukocytes. They convert arachidonic acid into hydroperoxy derivatives termed leukotrienes. The triggers for production are varied e.g. antigen binding in association with IgE in mast cells, activation of platelets. Leukotrienes are produced only when required.
The steps in production include:
LTA4 then forms the basis for the production of further leukotrienes:
LTC4 may be futher enzymatically converted to leukotrienes D4 and E4, LTD4 and LTE4 respectively, by amino acid substitution.
Last reviewed 01/2018