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- Crohn's disease
- methotrexate has been used effectively
with azathioprine unresponsive Crohn's disease - including fistulating Crohn's
- treatment with methotrexate in low dosage offers an effective
alternative to thiopurine maintenance in patients with Crohn's disease (2)
patients who have failed to respond to steroids, or who are intolerant of azathioprine
or 6-mercaptopurine, methotrexate has been shown to induce remission of inflammatory
bowel disease in 40 per cent of patients (3)
- a review suggests there is no evidence for the use of lower-dose oral methotrexate
- methotrexate is as efficacious in inducing remission as azathioprine, it
does not appear to work any faster (3)
NICE state with respect to use of methotrexate in Crohn's disease (5):
- Feagan BG et al (1995). Methotrexate for the treatment of Crohn's disease.
The North American Crohn's Study Group Investigators. NEJM; 332: 292-7.
- Drugs and Therapeutics Bulletin (2002); 39 (12): 91-95.
- Prescriber (2004), 15 (5)
- Alfadhli AAF, McDonald JWD, Feagan BG. Methotrexate for induction of remission
in refractory Crohn's disease (Cochrane Review). In: The Cochrane Library,
Issue 1, 2004. Chichester: John Wiley & Sons, Ltd.
- NICE (May 2019). Crohn's
disease Management in adults, children and young people
Last edited 06/2019