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Response to treatment cannot be expected before 2 months and may not occur
until after 6 months treatment.
- increasingly popular drug for
this condition in the USA
- once weekly dose
- long term tolerability
is better than that of gold, sulphasalazine, or penicillamine.
suppression starts earlier that with other slow-acting antirheumatics and patients
are less likely to stop treatment
- toxic effects include:
pneumonitis in 3% of patients
- bone marrow suppression in approximately
- opportunistic infections
- accelerated nodulosis of the hands
cirrhosis and liver failure - very rarely
- overall side-effects are
less common and can be minimised by folic acid supplementation
DR. Medical management of rheumatoid arthritis. BMJ 1993; 307:425-428.
Drug and Therapeutics Bulletin (1995). Methotrexate and rheumatoid arthritis.
- Current Problems in Pharmacovigilance 2000; 26: 10.
Last reviewed 01/2018