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2288 pages added, reviewed or updated during the last month (last updated: 19/4/2021)


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serum ACE levels in sarcoidosis

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Sarcoidal granulomas produce angiotensin-converting enzyme (ACE)

  • elevated ACE levels are seen in 60% of sarcoidosis patients
  • levels are influenced by gene polymorphism (1)

Although many clinicians check serum ACE levels, the importance of it in the diagnosis or managing sarcoidosis is debatable (1,2):

  • as a diagnostic tool it has limited sensitivity and specificity (1)
  • BTS guidelines also mention that serum ACE levels has a limited role in the diagnosis and it does not contribute to monitoring patients with pulmonary sarcoidosis when added to serial lung function and imaging (3)

Reference:

Last reviewed 01/2018

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