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Signs and allergic patterns of suspected drug allergy with timing of onset
Immediate, rapidly evolving reactions
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Onset usually less than 1 hour after drug exposure (previous exposure not always confirmed) |
Non-immediate reactions without systemic involvement
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Onset usually 6-10 days after first drug exposure or within 3 days of second exposure |
Non-immediate reactions with systemic involvement
Drug reaction with eosinophilia and systemic symptoms (DRESS) or drug hypersensitivity syndrome (DHS) characterised by:
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Onset usually 2-6 weeks after first drug exposure or within 3 days of second exposure |
Toxic epidermal necrolysis or Stevens-Johnson syndrome characterised by:
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Onset usually 7-14 days after first drug exposure or within 3 days of second exposure |
Acute generalised exanthematous pustulosis (AGEP) characterised by:
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Onset usually 3-5 days after first drug exposure |
Common disorders caused, rarely, by drug allergy:
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Time of onset variable |
Reference:
Last reviewed 01/2018
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