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2625 pages added, reviewed or updated during the last month (last updated: 15/4/2021)

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testosterone therapy in erectile dysfunction

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Testosterone therapy and erectile dysfunction

Testosterone therapy has been shown to improve sexual desire, morning erections and erectile function,1,2 particularly when:1-3

  • TT is <8nmol/L2 or calculated FT is <0.225nmol/L
  • Oral ED medications have failed and TT levels are <10.4nmol/L

In patients with ED, appropriate testosterone therapy (T therapy) may also reduce the need for more expansive and invasive second- and third-line treatments.4

A PDE5i can be co-prescribed to all men with ED when starting T therapy, in the absence of contraindications, because it can take many months for T therapy to correct ED.


  • 1. British Society of Sexual Medicine. Guidelines on the management of sexual problems in men: the role of androgens 2010. Available at: uploads/2017/05/UK_Guidelines_Androgens_Male_2010.pdf (Accessed May 2018).
  • 2. Dean JD, McMahon CG, Guay AT, et al. The International Society for Sexual Medicine's process of care for the assessment and management of testosterone deficiency in adult men. J Sex Med 2015;12:1660-1686.
  • 3. Buvat J, Montorsi F, Maggi M, et al. Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study). J Sex Med 2011;8:284-293.
  • 4. Lowe G, Bahnson R. Non-invasive management of primary phosphodiesterase type 5 inhibitor failure in patients with erectile dysfunction. Ther Adv Urol 2010;1:235-242.

Last edited 05/2018