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Testosterone therapy and erectile dysfunction
Testosterone therapy has been shown to improve sexual desire, morning erections
and erectile function,1,2 particularly when:1-3
- TT is <8nmol/L2 or calculated FT is <0.225nmol/L
- Oral ED medications have failed and TT levels are <10.4nmol/L
In patients with ED, appropriate testosterone therapy (T therapy) may also
reduce the need for more expansive and invasive second- and third-line treatments.4
A PDE5i can be co-prescribed to all men with ED when starting T therapy, in
the absence of contraindications, because it can take many months for T therapy
to correct ED.
- 1. British Society of Sexual Medicine. Guidelines on the management of sexual
problems in men: the role of androgens 2010. Available at: http://bssmorguk.ipage.com/wpcontent/
uploads/2017/05/UK_Guidelines_Androgens_Male_2010.pdf (Accessed May 2018).
- 2. Dean JD, McMahon CG, Guay AT, et al. The International Society for Sexual
Medicine's process of care for the assessment and management of testosterone
deficiency in adult men. J Sex Med 2015;12:1660-1686.
- 3. Buvat J, Montorsi F, Maggi M, et al. Hypogonadal men nonresponders to
the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels
with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction
(TADTEST study). J Sex Med 2011;8:284-293.
- 4. Lowe G, Bahnson R. Non-invasive management of primary phosphodiesterase
type 5 inhibitor failure in patients with erectile dysfunction. Ther Adv Urol
Last edited 05/2018