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Authoring team

  • randomized controlled trial that enrolled 5608 men (aged 45-73) and 997 postmenopausal women (aged 55-73) with average LDL and total cholesterol levels. The mean total cholesterol for the trial group was 5.71 mmol/l.
  • patients were randomized to lovostatin (20-40mg daily) or placebo in addition to a low cholesterol, low saturated fat diet
  • after an average follow-up of 5.2 years
    • the lovostatin group showed a significant reduction in incidence of acute major coronary events (by 37%), unstable angina (325) and myocardial infarctions (40%).
    • the beneficial effects of lovostatin therapy were evident after only one year of the study.
    • lovostatin group showed a reduction in LDL cholesterol by 25% and an increase in HDL cholesterol by 6%

  • Conclusions - lovostatin therapy reduced the risk of acute coronary artery events in a trial group with average total and LDL-cholesterols.Treatment benefits were apparent in men and women.


  • JAMA (1998), 279, 1615-22.

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