AIRE trial

2006 patients with acute myocardial infarction, complicated at any time by left ventricular failure, were randomised to:

• ramipril, an ACE-inhibitor, 5 mg twice daily
• placebo

Randomisation took place 3-10 days post-MI (mean 5 days).

Treatment with ramipril resulted in:

• an absolute reduction in mortality of 6%
• an odds reduction for death of 26%
• the prevention of 45 premature deaths per 1000 patient years

Reference:

• Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. (1993). Lancet, 342, 821-8.