This site is intended for healthcare professionals
Last reviewed dd mmm yyyy. Last edited dd mmm yyyy
D-dimers are specific degradation products of cross-linked fibrin that are released when the endogenous fibrinolytic system attacks the fibrin matrix of fresh venous thromboemboli.
The absence of a raised concentration of D-dimer implies that there is no fresh thromboembolic material undergoing dissolution in the deep veins or in the pulmonary arterial tree.
There is evidence that a normal D-dimer assay result was useful for ruling out pulmonary embolism (PE) in patients with a low pretest probability of PE or a nondiagnostic V/Q scan. A d-dimer below a certain cut point rules out PE with a high predictive value, at least in patients with a low or moderate clinical probability (4)
Conditions in which there may be a raised D-dimer include:
More detailed information concerning other causes and factors affecting D-dimer levels is included in the linked item.