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In renal impairment

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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As for any prescribing in renal impairment, appendix III in the BNF should be consulted.

Renal impairment is common, increasing in the elderly. Toxicity occurs frequently and is avoidable. Mechanisms include:

  • diminished renal excretion
  • plasma protein binding
  • altered drug action, e.g. CNS depressants, hypotensive vasodilators, anticoagulants, NSAIDS, acetylcholinesterase inhibitors.

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