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In renal impairment

Authoring team

As for any prescribing in renal impairment, appendix III in the BNF should be consulted.

Renal impairment is common, increasing in the elderly. Toxicity occurs frequently and is avoidable. Mechanisms include:

  • diminished renal excretion
  • plasma protein binding
  • altered drug action, e.g. CNS depressants, hypotensive vasodilators, anticoagulants, NSAIDS, acetylcholinesterase inhibitors.

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