Hyperlipidaemia (type II)
This is the most common primary hyperlipidaemia. Polygenic hypercholesterolaemia is, like height, the consequence of several genes together with acquired, largely nutritional factors.
Polygenic hypercholesterolaemia causes a similar pattern of hypercholesterolaemia to that seen in familial hypercholesterolaemia (FH) (but milder than FH with cholesterol levels >6.5 mmol/L. It is characterised by increased levels of LDL-cholesterol (> 4.0 mmol/L). Triglyceride levels are < 2.3 mmol/L.
There is an increased risk of coronary heart disease but xanthomata do not develop.
Note in familial hypercholesterolaemia characteristically total cholesterol is > 7.5mmol/L, LDL-cholesterol is > 5.0 mmol/L and triglyceride is < 2.3 mmol/L.
Related pages
- Mechanism of development of polygenic hypercholesterolaemia and familial combined hyperlipidaemia
- Causes
- Clinical features
- Management of hyperlipidaemia
- WHO/Fredrickson classification of primary hyperlipidaemias
- Hyperlipidaemia
- Genetic lipoprotein disorders
- Referral criteria from primary care - high cholesterol
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