Interleukin-6
Interleukin-6 is a protein cytokine involved in inflammatory and immune responses. It is produced by:
- mononuclear phagocytes
- fibroblasts
- keratinocytes
- endothelial cells
It is produced when the given cell encounters endotoxin. It is regulated by interleukin-1 and tumour necrosis factor.
Its effects include:
- B-lymphocyte differentiation and immunoglobulin production
- synthesis of acute phase proteins
- pyrogen via its central action on prostaglandins
- increases IL-2 and IL-2 receptor expression
- inhibits the formation of TNF
Reference
- Akdis M et al. Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2016 Oct;138(4):984-1010.
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