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Loffler's endocarditis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Eosinophilic endomyocardial disease is characterized by:

  • endomyocardial fibrosis
  • a high incidence at temperate latitudes
  • large mural thrombi
  • eosinophilia with infiltration of organs especially the heart (causing restrictive cardiomyopathy)
  • rapid fatality

This disease is closely related to the African condition of endomyocardial fibrosis (qv).

Treatment measures include:

  • suppression of eosinophilia e.g. prednisolone or hydroxycarbamide (former British Approved Name, hydroxyurea)
  • digoxin
  • diuretics

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