This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Renal damage and ACE inhibitor use in renal artery stenosis

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The glomerular filtration pressure is determined by three main variables:

  • systemic blood pressure
  • vasomotor tone in the afferent arteriole
  • vasomotor tone in the efferent arteriole

In cases of bilateral renal artery stenosis (or unilateral stenosis if there is only one functional kidney):

  • the glomerular filtration pressure is dependent on the vasoconstriction of the efferent arteriole because the resistance of the afferent blood vessels has been pathologically increased
    • vasoconstriction of the efferent arteriole is mediated by angiotensin II
    • administration of an ACE inhibitor abolishes the vasoconstriction of the efferent arteriole resulting in an abrupt fall in the glomerular filtration rate
    • the deterioration in renal function due to ACE inhibitors is usually reversible on stopping the drug

The EMC states that a contraindication to use of an ACE inhibitor is

  • significant bilateral renal artery stenosis or renal artery stenosis in a single functioning kidney (1)

Reference:


Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.