This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Changes in the neuroendocrine system in heart failure

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The neuroendocrine systems which are most profoundly affected by heart failure are:

Renin-aldosterone system:

  • the renin-aldosterone system is inactive or only slightly activated in untreated heart failure
  • diuretics greatly stimulate renin production
  • angiotensin II increases peripheral vascoconstriction and hence the afterload on the heart
  • angiotensin II causes constriction of the efferent arteriole in the kidney:
    • in the normal kidney this may maintain the glomerular filtration rate in the face of reduced arterial blood pressure
    • in a kidney which is already dependent on angiotensin II e.g. in renal artery stenosis, further angiotensin II may cause reduced renal function
  • angiotensin II may be directly toxic to myocytes

Autonomic nervous system:

  • the sympathetic system is activated
  • the parasympathic tone is reduced
  • there is no good explanation for these changes
  • increased sympathetic activity may be detected by analysing heart rate variability
  • increased sympathetic activity is associated with fatal arrhythmias

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.