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Troponin complex

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Troponin is an important component of the contractile machinery of skeletal and cardiac muscle. Troponin is a complex of three polypeptide chains:

  • Troponin C (18 kd)
  • Troponin I (24 kd)
  • Troponin T (37 kd)

Troponin C binds calcium, Troponin I binds actin, Troponin T binds tropomyosin.

The troponin complex is located in the thin filaments at intervals set by the length of a tropomyosin unit. Each troponin complex regulates the interactions of 7 actin units.

During skeletal and cardiac muscle contraction the binding of calcium to Troponin C induces a conformational change which is transmitted to other members of the troponin complex and then to tropomyosin resulting in shortening of the actin-myosin complex and muscle contraction.

Reference

  1. Potter JM, Hickman PE, Cullen L. Troponins in myocardial infarction and injury. Aust Prescr. 2022 Apr;45(2):53-57

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