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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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A blister is an important physical sign in dermatology. Blisters can be divided by size into:

  • vesicles which are less than 0.5 cm in diameter
  • bullae which are greater than 0.5 cm in diameter

Blisters can also be divided according to the level of the histological split into:

  • intra-epidermal blisters
  • sub-epidermal blisters

Intra and sub-epidermal blisters can often be differentiated clinically since intra-epidermal blisters are thin roofed and easily ruptured.

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