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The treatment of Gorlin's Syndrome should ideally be co-ordinated by a specialist as input may be required from many teams including dermatology, plastic surgery, dentists, cardiologists, oncologists and orthopaedic surgeons.

Basal cell carcinoma lesions can be treated with surgical excision when they arise if they are relatively few in number. Large and rapidly developing crops of lesions may require alternative modalities such as laser ablation, photodynamic therapy or 5-fluouracil cream. Retinoid therapy may have some utility as a prophylactic treatment for slowing the development of skin lesions.

Odontogenic keratocysts are removed but they have a high tendency to recur.

More rarely, associated medulloblastoma may be treated with resection, chemotherapy and radiation.

Gorlin's Syndrome patients should be counselled to avoid sun and radiographic exposure due to their suggested heightened sensitivity to potential mutagenesis.

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