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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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A granuloma - plural granulomas or granulomata - is a discrete region of granulomatous inflammation defined by its histology after biopsy:

  • epitheloid cells at its centre
  • fusion of epitheloid cells to form a foreign body giant cell - the key feature

There may also be:

  • lymphocyte mantle surrounding epitheloid cells
  • evidence of aetiological agent e.g. tuberculosis bacillus
  • fibroblast proliferation with or without fibrin deposition
  • plasma cells
  • less frequently, neutrophils

A tuberculous granuloma is termed a tubercle. Rheumatoid nodules of rheumatoid arthritis contain granulomas.

The causes of granulomas are detailed under granulomatous inflammation in the submenu.

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