Clinical adverse events on methotrexate
- mouth ulcers
- stomatitis
Stop if severe, reduce dose if mild/moderate. Consider carbenoxalone or difflam mouth washes. Consider other causes.
- cough or dyspnoea
Stop drug. Seek advice. Chest X-ray and pulmonary function tests.
- nausea/anorexia
Split dose, reduce dose. Take with food. Try anti-emetic. Stop if unacceptable
- increased nodule formation
Reassure. Stop if unacceptable
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