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Thrombocytopenia with cavernous haemangioma

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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This is the association of cutaneous vascular tumours, life-threatening coagulopathy, and profound thrombocytopaenia (1,2).

The thrombocytopaenia is thought to be secondary to platelet trapping in the aggressive tumours (3).

Mulliken et al state that Kasabach-Merritt syndrome does not occur with the common infantile haemangioma (1). However there are older case reports where Kasabach-Merritt syndrome has occurred in the context of cutaneous cavernous haemangioma and strawberry naevi (4,5).

It is generally associated with kaposiform haemangioendothelioma and tufted angioma (2)

  • the tufted angioma and kaposiform haemangioendothelioma are together responsible for the great majority of cases of the Kasabach-Merritt phenomenon (6)

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