Management of Conn's syndrome

Seek expert advice

• identification of underlying cause
• if due to adenoma - surgery after 4 to 6 weeks of spironolactone therapy
• if due to adrenal hyperplasia - spironolactone or amiloride is generally sufficient

Note - approximately 30% of patients with primary aldosteronism (PA) who undergo adrenal venous sampling demonstrate clear lateralisation, with definite aldosterone production by one adrenal and contralateral suppression of the other. These patients are candidates for unilateral adrenalectomy, which results in cure of hypertension in 50% to 60%, and significant improvement in the remainder. (1)

Reference

1. Stowasser M, Gordon RD. Primary aldosteronism. Best Pract Res Clin Endocrinol Metab. 2003 Dec;17(4):591-605.