This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Aetiology of diabetic nephropathy

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Whilst various factors such as blood pressure and blood sugar may play a role in the development of diabetic nephropathy, it seems likely that there is a significant genetic influence to its development.

  • initial evidence for diabetic retinopathy (DR) heritability came from twin studies
    • concordance rates for the presence and severity of DR was higher in monozygotic than in the dizygotic twins (1)
    • there is a higher concordance of DR in T2D monozygotic twins (95%) than in T1D monozygotic twins (68%), suggesting that in T1D the initiation and development of its complications are less dependent on genetic factors than in T2D (2)
  • heritability has been estimated to be as high as 27% for DR and 52% for proliferative diabetic retinopathy (PDR), a more advanced form of the disease (3,4)

Reference:

  • Pyke DA, Tattersall RB. Diabetic retinopathy in identical twins. Diabetes. 1973;22(8):613-618
  • Leslie RD, Pyke DA. Diabetic retinopathy in identical twins. Diabetes. 1982;31(1):19-21.
  • Hietala K, Forsblom C, Summanen P, Groop PH. Heritability of proliferative diabetic retinopathy. Diabetes. 2008;57(8):2176-2180
  • Looker HC, Nelson RG, Chew E, Klein R, Klein BE, Knowler WC, Hanson RL. Genome-wide linkage analyses to identify Loci for diabetic retinopathy. Diabetes. 2007;56(4):1160-1166

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.