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Drugs causing syndrome of inappropriate ADH

Authoring team

The drugs most commonly implicated in SIADH are:

  • thiazide diuretics
  • vincristine
  • vinblastine
  • cyclophosphamide, at high or low dose

Others include:

  • chlorpromamide
  • carbamazepine
  • phenothiazines
  • tricyclic antidepressants
  • clofibrate
  • oxytocin
  • vasopressin
  • morphia
  • barbiturates
  • nicotine

Reference:

  • McCarron MS et al (1995). Water intoxication after low dose cyclophosphamide. BMJ, 311,292.
  • Felig P et al (2001) Endocrinology and Metabolism, McGraw-Hill.

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