Clinical features

Patients are frequently asymptomatic.

In others, presentation may be with features such as:

• mild hypertension
• lethargy
• muscular weakness
• polyuria and polydipsia
• persistent hypokalaemia
• intermittent paraesthesiae, tetany and occasionally paralysis

There is an increasing frequency in the diagnosis of primary aldosteronism (1):

• principal reason for the increasingly frequent diagnosis of this disease, once viewed as rare, is that normokalemic Conn's syndrome is now recognized as an independent disease entity
• normal serum potassium may be present in up to 38% of patients, especially in patients with adrenal hyperplasia or familial aldosteronism
• found in 5% to 18% of patients with high blood pressure

Reference:

• Aronova A, Fahey TJ III, Zarnegar R. Management of hypertension in primary aldosteronism. World J Cardiol. 2014 May 26;6(5):227-33