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Clinical features

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

With milder expressions of the syndrome, the clinical manifestations are subtle. At the other extreme more overt expressions of acute hypocalcaemia may be present:

  • increased neuromuscular excitability:
    • may cause Chvostek's sign, tetany, carpopedal spasms, laryngeal stridor and convulsions

  • mental changes - ranging from irritability to depression and frank psychosis

  • neurological signs suggesting an intracranial tumour with elevated CSF pressure e.g. papilloedema

  • intracranial calcification visualised by skull radiology - particularly, in the basal ganglia

  • calcification of lens, leading to formation of cataracts

  • abnormalities of cardiac conduction - mainly prolonged Q-T intervals and T-wave changes

  • abnormalities of dentition with defective enamel, dental hypoplasia, and delayed eruption of teeth

  • alopecia with premature greying

  • chronic mucocutaneous candidiasis is common in autoimmune hypoparathyroidism

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