Impact of change in bodyweight and chance of remission in type 2 diabetes

An analysis of data from 22 studies it is estimated that the probability of achieving complete type 2 diabetes remission increases by 2.17% (95% CI: 1.94 to 2.40) and partial remission by 2.74% (2.48 to 3.0) for every 1% decrease in body weight (1):

• for every 1 percentage point decrease in bodyweight, the probability of reaching complete remission increased by 2·17 percentage points (95% CI 1·94–2·40) and the probability of reaching partial remission increased by 2·74 percentage points (2·48–3·00)
• no significant or appreciable associations were observed between age, sex, race, diabetes duration, baseline BMI, HbA1c, insulin use, or type of bodyweight loss intervention and remission

Reference:

1. Kanbour, Sarah et al. Impact of bodyweight loss on type 2 diabetes remission: a systematic review and meta-regression analysis of randomised controlled trials. Lancet Diabetes & Endocrinology February 26th, 2025.