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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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In tumours associated with the MEN-1 syndrome there is a deletion of a tumour suppressor gene on chromosome 11.

30-40% of somatotroph tumours have a mutation in the gsp oncogene which codes for the alpha subunit of Gs; elevation of intracellular cAMP seems to play a role in secretory overactivity.

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