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Aetiology

Authoring team

Causes may be classified as:

  • drug-induced
    • selective serotonin reuptake inhibitors
    • carbamazepine
    • tricyclic antidepressants
    • haloperidol
  • neoplastic
    • small cell lung cancer
    • mesothelioma
    • GI tract malignancy
    • pancreatic malignancy
  • pulmonary
    • pneumonia - especially Legionella and Mycoplasma
    • tuberculosis
    • abscess
  • CNS
    • tumour
    • meningitis, encephalitis
    • head injury
    • subarachnoid or subdural haemorrhage
  • miscellaneous
    • Guillain–Barre syndrome
    • multiple sclerosis
    • acute intermittent porphyria
    • idiopathic (1)

Reference:

  1. Hannon MJ, Thompson CJ. The syndrome of inappropriate antidiuretic hormone: prevalence, causes and consequences. Eur J Endocrinol. 2010;162 Suppl 1:S5-12

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