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Syndrome of inappropriate antidiuretic hormone secretion

Authoring team

This is one of the most common causes of hyponatraemia; patients produce an inappropriately concentrated urine when there is no discernible stimulus for release of antidiuretic hormone (1,2).

The following criteria should be fulfilled before a diagnosis of SIADH can be made:

  • persistent excretion of concentrated urine with no reason for ADH release
  • normal renal and adrenal function
  • no oedema or hypovolaemia should be present

Reference:

  1. Lawless SJ, Thompson C, Garrahy A. The management of acute and chronic hyponatraemia. Ther Adv Endocrinol Metab. 2022 May 14;13:20420188221097343.
  2. Adrogué HJ, Tucker BM, Madias NE. Diagnosis and management of hyponatremia: a review. JAMA. 2022 Jul 19;328(3):280-91.

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