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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team


  • diabetes
  • gout
  • may exacerbate systemic lupus erythematosus
  • pregnancy and breast feeding
  • ineffectual if renal impairment - serum creatinine > 150 micromol/litre; use a loop diuretic instead
  • hepatic impairment
  • hyperlipidaemia is not a contraindication because the long-term effect of low doses on lipids is trivial


  • refractory hyponatraemia, hypokalaemia, hypercalcaemia
  • severe hepatic and renal impairment
  • symptomatic hyperuricaemia
  • Addison's disease

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