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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Radiation therapy is generally reserved for patients in whom both surgical and medical interventions have not provided biochemical control (1).

  • reduces growth hormone concentrations in 90% of patients

  • prevents regrowth of the tumour in 99%

  • possible complications include:
    • hypopituitarism:
      • commonest side effect
      • about half of patients may require replacement for adrenocorticotrophin hormone, thyroid stimulating hormone, or gonadotrophin deficiency by 10 years
    • visual loss
    • brain necrosis
    • tumorigenesis


  • stereotactic radiosurgery techniques have advantages over conventional fractionated radiotherapy
    • better targeting and reduced radiation exposure to surrounding tissue and shorter time to achieve control of IGF-1 and GH levels
    • extremely large tumor volumes or tumors near the chiasm are not amenable to radiosurgery - therefore such cases require fractionated radiotherapy
    • with either fractionated radiotherapy or radiosurgery
      • may take many years to achieve the full therapeutic effect and continued medical treatment will usually be needed.


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