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Triptans and St John's wort

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St John's wort (SJW) interacts with triptans (sumatriptan, naratriptan, rizatriptan, zolmitriptan) and may lead to increased serotonergic effects with an increased incidence of adverse reactions.

If a patient is taking SJW and triptans it is advised that the patient stops taking SJW.

Reference:

  • CEM/CMO/2000/4

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