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Vestibular sedatives

Authoring team

Vestibular sedatives include:

  • prochlorperazine
  • cinnarizine
  • betahistine
  • scopolamine

The use of vestibular sedatives should be very short-term only (less than a week) because of the associated potential risk of unsteadiness and falls, particularly in the elderly. (1)

Note - prochlorperazine can cause significant extrapyramidal symptoms, including acute dystonia, tardive dyskinesia, Parkinsonism, akathisia, and neuroleptic malignant syndrome. (2)

Reference

  1. Koch A et al. The Neurophysiology and Treatment of Motion Sickness. Dtsch Arztebl Int. 2018 Oct 12;115(41):687-696
  2. Chokhawala KP, Stevens L. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Feb 26, 2023. Antipsychotic Medications.

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