For patients being switched to treatment with losartan
- from calcium antagonist - discontinue calcium antagonist and initiate angiotensin-II antagonist
- beta blocker - do not withdraw the beta-blocker immediately, but titrate in accordance with the manufacturer's instructions and initiate therapy with angiotensin-II antagonist
- ACE inhibitor - if the patient is already stabilised on the ACEI, discontinue the ACEI, and initiate therapy with losartan
- diuretic - discontinue the diuretic 2-3 days before starting angiotensin-II antagonist
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