Results

Withdrawal from digoxin resulted in:

• worsening heart failure in 23 patients, compared to 4 in the group continuing with digoxin (p<0.001)
  
  
• a relative risk of worsening heart failure of 5.9 vs. the digoxin group
  
  
• a reduction in maximal exercise tolerance (p=0.01)
  
  
• a lower quality of life (p=0.04)
  
  
• decreased ejection fraction (p=0.001)
  
  
• increased heart rate (p=0.001)