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SOLVD - treatment arm

Authoring team

This multicentre, randomised, double-blind, placebo-controlled trial enrolled 2569 patients with reduced left ventricular function (ejection fraction <35%) and symptomatic heart failure.

The addition of enalapril to the conventional heart failure therapy was found to significantly:

  • reduce mortality by 16%
  • reduce hospitalisation for heart failure by 26%

Reference:

  • SOLVD Investigators. (1991). N Engl J Med. 325, 293-302.

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