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Aetiology with respect to frequency

Authoring team

Inherited and acquired factors both contribute to the development of GORD (1)

  • the prevalence of reflux symptoms is high in the parents of affected people
  • concordance of reflux disease is higher in identical twin pairs
  • genetic factors contribute about 18-31% to the cause of GORD

Common associated conditions are:

  • sliding hiatus hernia
  • pyloric stenosis
  • pregnancy

Less common associations are:

  • diabetic neuropathy
  • scleroderma

Study evidence has emphasized the significance of lifestyle factors (1)

  • these predisposing lifestyle factors include:
    • obesity
    • smoking
    • alcohol
    • large, late meals (1)

Reference:

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