High risk groups
The following groups are at high risk of having coeliac disease:
- first degree relatives - 5-11% chance of being affected
- second degree relatives – around 2.5%
- genetic susceptibility
- genes encoding HLA DQ2
- genes encoding HLA DQ8
- other autoimmune conditions
- insulin-dependent diabetes - approximately 2-4% are affected by coeliac disease.
- autoimmune thyroid disease - approximately 2-4% are affected by coeliac disease.
- increased incidence in patients with Down's syndrome.
- selective IgA deficiency - approximately 10% are affected by coeliac disease
Reference:
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