Helicobacter pylori associated gastritis

Previously classified as a type B gastritis. Histological gastritis is almost always present if helicobacter is present. H. pylori infection is carries a significant risk for the development of atrophic gastritis and intestinal metaplasia. Also it appears to have a causative role in gastric carcinogenesis.

Prevalence: (1)

• in the developed world it is more common in the older age-groups, and this may imply a cohort effect
• once established H. pylori infection is generally life- long unless either the organism is eradicated, or, the severity of the gastritis makes the microenvironment inhospitable for the bacteria e.g. intestinal metaplasia

Reference

1. Hooi JKY et al. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 2017 Aug;153(2):420-429.