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Pathological classification

Authoring team

Three main patterns are recognised:

  • micronodular - characterised by:
    • small, uniformly sized, regenerative nodules less than 3 mm in diameter, separated by thick fibrous bands
    • most commonly seen in alcoholism, Wilson's disease, alpha-1 anti-trypsin deficiency

  • macronodular - characterised by:
    • nodules of variable size, mostly exceeding 3 mm in diameter
    • normal lobules may occur in the large nodules
    • most commonly seen in viral or autoimmune forms of chronic active hepatitis; may occur in alcoholics, especially in those who have stopped drinking

  • mixed:
    • regeneration in a micronodular pattern resulting in a macronodular or mixed pattern

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