This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Inhibition of gastric acid secretion

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The inhibition of gastric acid secretion may be achieved in two ways:

  • H2 antagonists:
    • ranitidine 150 mg bd or 300 mg nocte for 4-8 weeks
    • ranitidine is preferred over cimetidine because it has fewer side effects and drug interactions
    • both drugs are effective for the treatment of gastric and duodenal ulceration
    • relapse of ulcer disease is common when therapy is discontinued

  • proton pump inhibitors:
    • the most commonly used example is omeprazole
    • acts for 24 hr (longer than H2 inhibitors)
    • are the first-line treatment for management of dyspepsia in primary care (1)


  1. NICE (August 2004). Dyspepsia - management of dyspepsia in adults in primary care

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page