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Side effects

Authoring team

A possible side effect is the development of pulmonary fibrosis - the changes induced by the drug may resolve despite continuing treatment.

Other side effects include:

  • impairment of liver function
  • bone marrow suppression
  • pneumonitis
  • megaloblastic anaemia
  • nausea, vomiting and anorexia
  • impaired fertility, menstrual dysfunction and amenorrhoea, oligospermia
  • teratogenic - should not be used in pregnancy, and conception should be avoided for at least 3 months after treatment with methotrexate
  • skin ulceration in psoriatic patients and rarely painful erosion of psoriatic plaques have been reported (1)

The summary of product characteristics must be consulted before prescribing this drug.

Reference:

  • Wyeth (February 2001). Methotrexate injection 25mg/ml and methotrexate 2.5mg tablets. Summary of Product Characteristics and Data Sheet.

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