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Laboratory events on azathioprine

Authoring team

  • leucopaenia <3.5*10^9/l then Stop and seek advice

  • neutropaenia <2.5*10^9/l then Stop and seek advice

  • thrombocytopaenia <150*10^9/l then Stop and seek advice

  • macrocytosis >100 then Check B12 and folate (Dose related)

  • sequential falls in WCC or PMNs: >10% on 3 occasions then Stop and seek advice

  • sequential falls in platelets: >10% on 3 occasions then Stop unless falls are from a high level, which is a response to treatment

  • elevation of LFTs (AST,ALT, not ALP) >3*normal then Stop and repeat LFTs (Mild transaminitis is common)

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