This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Laboratory event in methotrexate monitoring

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Event

Value

Action

Leucopaenia

<3.5*10^9/l

Stop & seek advice

Neutropaenia

<2.5*10^9/l

Stop & seek advice

Thrombocytopaenia

<150*10^9/l

Stop & seek advice

Macrocytosis

>100

Macrocytosis >100 Check B12 and folate

Sequential falls in WCC or PMNs

>10% on occasions

Stop & seek advice

Sequential falls in platelets

Sequential falls >10% on 3 occasions

Stop unless falls are from in platelets from a high level, which is a response to treatment

Elevation of LFTs (AST, ALT, not ALP)

>3x normal

Stop & repeat LFTs (AST, ALT, not ALP) Mild transaminitis is common

Falls in albumin

>5g/l

Stop. Repeat LFTs. (early sign of liver toxicity)

 


Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.