Mode of action
Proton pump inhibitors work by inhibition of the membrane proton pump in gastric parietal cells. It results in a dose-dependent inhibition of gastric acid secretion.
Omeprazole results in the suppression of acid production with a higher efficacy and a longer duration of action than can be achieved with a H2 antagonist, e.g. ranitidine (1).
Reference:
- Prescriber's Journal (1992) 32, 4, 162-167
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