This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Oxidative deamination

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Deamination is a means of amino acid degradation that predominantly occurs in the liver. It entails the loss of an amino (-NH2) group that is used to produce ammonia. Ammonia is free to enter the urea cycle.

The amino acid is converted to an oxoacid. The oxoacid is free to enter other metabolic pathways; several tricarboxylic acid cycle intermediates are produced in this way. During the reaction, a coenzyme is usually reduced when the amino acid is oxidized to an imino acid by dehydrogenation. The coenzyme may be FAD or NAD depending on the enzyme. The reduced coenzyme can be used to generate ATP.

Examples of enzymes involved in oxidative deamination include amino acid oxidase and glutamate dehydrogenase.

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page