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Aetiology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The cause of pancreatic carcinoma is unknown.

The following risk factors are known to be associated with the development of pancreatic carcinoma:

  • smoking
  • alcohol
  • increased BMI
  • diabetes
  • chronic pancreatitis
  • family history of pancreatic cancer
  • familial cancer syndromes
    • BRCA1, BRCA2
    • familial adenomatous polyposis (FAP)
    • Peutz-Jeghers syndrome
    • Lynch syndrome
    • von Hippel-Lindau syndrome
    • Multiple endocrine neoplasia type 1
  • other medical conditions
    • inflammatory bowel disease
    • periodontal disease
    • peptic ulcer disease (1)

Certain industries seem to impart a high risk to their workers; occupational exposure to coal gas and aluminium increase the risk.

Coffee consumption is no longer considered to be a risk factor.

Reference:

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